LDB2 Antibody (C-term)

O55203; Q9W676; NP_001124306.1; NP_001281.1

Genes encoding LIM domain-binding factors were initially
isolated in a screen for proteins that physically interact with the
LIM domains of nuclear proteins (summarized by Semina et al., 1998
[PubMed 9799849]). These proteins, such as the one encoded by the
LDB2 gene, are capable of binding to a variety of transcription
factors and are likely to function at enhancers to bring together
diverse transcription factors and form higher order activation
complexes or to block formation of such complexes (Jurata and Gill,
1997 [PubMed 9315627]). The family of genes encoding LIM
domain-binding factors includes 2 members isolated from the mouse,
Clim1 (Bach et al., 1997 [PubMed 9192866]) and Clim2/Lbd1/Nli
(Agulnick et al., 1996 [PubMed 8918878]; Jurata et al., 1996
[PubMed 8876198]; Bach et al., 1997 [PubMed 9192866]) and their
homologs cloned from the frog, chicken, and fly. The fact that LIM
domain-binding factors are likely to be involved in the
coordination of the transcriptional activity of many diverse
factors might implicate them in human phenotypes characterized by
multiple affected sites.

9079

H

42793

HUMAN

NP_001124306.1; NP_001281.1