ADRA2C Antibody (C-term)

Primary Antibodies; Antibody Collections; Neuroscience; Signal Transduction; GPCR Antibodies; Druggable G protein-coupled receptors (GPCRs)

Alpha-2-adrenergic receptors are members of the Gprotein-coupled receptor superfamily. They include 3 highlyhomologous subtypes: alpha2A, alpha2B, and alpha2C. These receptorshave a critical role in regulating neurotransmitter release fromsympathetic nerves and from adrenergic neurons in the centralnervous system. The mouse studies revealed that both the alpha2Aand alpha2C subtypes were required for normal presynaptic controlof transmitter release from sympathetic nerves in the heart andfrom central noradrenergic neurons. The alpha2A subtype inhibitedtransmitter release at high stimulation frequencies, whereas thealpha2C subtype modulated neurotransmission at lower levels ofnerve activity. This gene encodes the alpha2C subtype, whichcontains no introns in either its coding or untranslated sequences.

RB34564

Affinity Purified Rabbit Polyclonal Antibody (Pab)

M, Rat

HUMAN

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Synthetic Peptide