LRP5 Antibody (C-term)

Q91VN0; NP_002326.2

This gene encodes a transmembrane low-density lipoprotein
receptor that binds and internalizes ligands in the process of
receptor-mediated endocytosis. This protein also acts as a
co-receptor with Frizzled protein family members for transducing
signals by Wnt proteins and was originally cloned on the basis of
its association with type 1 diabetes mellitus in humans. This
protein plays a key role in skeletal homeostasis and many bone
density related diseases are caused by mutations in this gene.
Mutations in this gene also cause familial exudative
vitreoretinopathy.

4041

M

1163-1190

This LRP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1163-1190 amino acids from the C-terminal region of human LRP5.