Mouse Akt1 Antibody (N-term)

Primary Antibodies; Cancer; Cardiovascular; Cell Biology; Neuroscience; Signal Transduction

This gene encodes the founding member of the Aktserine-threonine protein kinase gene family that also includes Akt2and Akt3. This kinase is a major downstream effector of thephosphatidylinositol 3-kinase (PI3K) pathway that mediates theeffects of various growth factors such as platelet-derived growthfactor (PDGF), epidermal growth factor (EGF), insulin andinsulin-like growth factor I (IGF-I). It is activated throughrecruitment to cellular membranes by PI3K lipid products and byphosphorylation by 3-phosphoinositide dependent kinase-1. It thenfurther phosphorylates different downstream proteins in response tovarious extracellular signals and thus plays a pivotal role inmediating a variety of cellular processes, such as glucosemetabolism, glycogen biosynthesis, protein synthesis and turn over, inflammatory response, cell survival (anti-apoptosis) anddevelopment. Alternatively spliced transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].

RB34732

Affinity Purified Rabbit Polyclonal Antibody (Pab)

H

MOUSE

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Synthetic Peptide