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TLR3 Antibody

TLR3 Antibody

Item no.	ABC-AP1503e-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Neuroscience Neural Lineage Markers Antibodies Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Polyclonal
Applications	Western Blot, Immunohistochemistry
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Toll-like receptor 3, CD283, TLR3
Available
Primary Accession	O15455
Other Accession	Q99MB1
Antigen Type	Recombinant Protein
Bio Background	The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.
Bio References	Heinz, S., et al., J. Biol. Chem. 278(24):21502-21509 (2003). Sarkar, S.N., et al., J. Biol. Chem. 278(7):4393-4396 (2003). Matsumoto, M., et al., Biochem. Biophys. Res. Commun. 293(5):1364-1369 (2002). Takami, M., et al., J. Immunol. 169(3):1516-1523 (2002). Kadowaki, N., et al., J. Exp. Med. 194(6):863-869 (2001).
Gene ID	7098
Gene Name	TLR3
Reactivity	H, M
Calculated MW	103829
Antigen Source	HUMAN
Target/Specificity	This TLR3 antibody is generated from rabbits immunized with TLR3 recombinant protein.
NCBI Accession	NP_003256.1

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Amount: 80 ul

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