C4BPB Antibody (Center)

Synthetic Peptide

This gene encodes a member of a superfamily of proteins
composed predominantly of tandemly arrayed short consensus repeats
of approximately 60 amino acids. A single, unique beta-chain
encoded by this gene assembles with seven identical alpha-chains
into the predominant isoform of C4b-binding protein, a multimeric
protein that controls activation of the complement cascade through
the classical pathway. C4b-binding protein has a regulatory role in
the coagulation system also, mediated through the beta-chain
binding of protein S, a vitamin K-dependent protein that serves as
a cofactor of activated protein C. The genes encoding both alpha
and beta chains are located adjacent to each other on human
chromosome 1 in the regulator of complement activation gene
cluster. Alternative splicing gives rise to multiple transcript
variants.

Polyclonal

725

Affinity Purified Rabbit Polyclonal Antibody (Pab)

C4BPB Antibody (Center) (Cat. #AP16055c) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the C4BPB antibody detected the C4BPB protein (arrow).

1:1000

WB

NP_001017365.1; NP_001017367.1; NP_000707.1

28357

HUMAN

NP_000707.1; NP_001017364.1; NP_001017365.1; NP_001017366.1; NP_001017367.1