ITGB7 Antibody (C-term)

Primary Antibodies; Signal Transduction; Host cell receptor for virus entry; Viral entry into host cell; Inflammation mediated by chemokine and cytokine signaling; Intestinal immune network for IgA production; Integrin Antibodies

Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp12, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp12. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

RB30295

Affinity Purified Rabbit Polyclonal Antibody (Pab)

86903

737-765

WB: 1:1000