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WWTR1 Antibody (C-term)

WWTR1 Antibody (C-term)

Item no.	ABC-AP16419b-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Antibodies Western Blot Primary Antibodies
Type	Antibody Polyclonal
Applications	Western Blot
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	WW domain-containing transcription regulator protein 1, Transcriptional coactivator with PDZ-binding motif, WWTR1, TAZ
Available
Primary Accession	Q9GZV5
Other Accession	Q9EPK5; NP_001161752.1; NP_056287.1
Antigen Type	Synthetic Peptide
Bio Background	Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
Bio References	Remue, E., et al. FEBS Lett. 584(19):4175-4180(2010) Strakova, Z., et al. Biol. Reprod. 82(6):1112-1118(2010) Cho, H.H., et al. J. Cell. Physiol. 223(1):168-177(2010) McGeachie, M., et al. Circulation 120(24):2448-2454(2009) Ferrara, A.M., et al. J. Endocrinol. Invest. 32(3):238-241(2009)
Gene ID	25937
Gene Name	WWTR1
Reactivity	H
Predicted	M
Calculated MW	44101
Antigen Region	370-398
Antigen Source	HUMAN
Target/Specificity	This WWTR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 370-398 amino acids from the C-terminal region of human WWTR1.
NCBI Accession	NP_001161750.1; NP_001161752.1; NP_056287.1

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Amount: 80 ul

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