HLA-DMB Antibody (Center)

Primary Antibodies; Immunology; Immunity; T cell activation; Lysosome; Allograft rejection; Intestinal immune network for IgA production

HLA-DMB belongs to the HLA class II beta chain paralogues.This class II molecule is a heterodimer consisting of an alpha(DMA) and a beta (DMB) chain, both anchored in the membrane. It islocated in intracellular vesicles. DM plays a central role in thepeptide loading of MHC class II molecules by helping to release theCLIP (class II-associated invariant chain peptide) molecule fromthe peptide binding site. Class II molecules are expressed inantigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and itsgene contains 6 exons. Exon one encodes the leader peptide, exons 2and 3 encode the two extracellular domains, exon 4 encodes thetransmembrane domain and exon 5 encodes the cytoplasmic tail.

RB36087

Affinity Purified Rabbit Polyclonal Antibody (Pab)

28931

104-133

WB: 1:1000