RGS14 Antibody (Center)

Primary Antibodies; Signal Transduction; Inflammation mediated by chemokine and cytokine signaling

This gene encodes a member of the regulator of G-proteinsignaling family. This protein contains one RGS domain, twoRaf-like Ras-binding domains (RBDs), and one GoLoco domain. Theprotein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein(GAP), the protein increases the rate of conversion of the GTP toGDP. This hydrolysis allows the G alpha subunits to bind Gbeta/gamma subunit heterodimers, forming inactive G-proteinheterotrimers, thereby terminating the signal. Alternatetranscriptional splice variants of this gene have been observed buthave not been thoroughly characterized.

RB35943

Affinity Purified Rabbit Polyclonal Antibody (Pab)

61447

223-251

WB: 1:1000