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RB1 Antibody (Center S249)

RB1 Antibody (Center S249)

Item no.	ABC-AP16868c
Manufacturer	Abcepta
Amount	400 ul
Category	Oncology Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Cell Biology Cell Status Western Blot Senescence Primary Antibodies Astrocytoma By Organ Bladder Cancer Bone Cancer
Type	Antibody Polyclonal
Applications	WB
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Citations	Liao, C.C., et al. J. Biol. Chem. 285(43):33134-33143(2010) Kim, T.R., et al. Biochem. Biophys. Res. Commun. 400(1):100-105(2010) Hirschi, A., et al. Nat. Struct. Mol. Biol. 17(9):1051-1057(2010) Tooley, C.E., et al. Nature 466(7310):1125-1128(2010) Dimaras, H., et al. Transl Res 156(2):91-97(2010)
NCBI	NP_000312.2
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Retinoblastoma-associated protein,p105-Rb,pRb,Rb,pp110,RB1
Similar products	Rb, RB1, Retinoblastoma-associated protein, p105-Rb, pRb, pp110
Available
Manufacturer - Category	Primary Antibodies; Cancer; Cell Biology; Viral process; Host-virus interaction
Manufacturer - Targets	This RB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-256 amino acids from the Central region of human RB1.
Bio Background	The protein encoded by this gene is a negative regulatorof the cell cycle and was the first tumor suppressor gene found.The encoded protein also stabilizes constitutive heterochromatin tomaintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factorE2F1. Defects in this gene are a cause of childhood cancerretinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB36870
Gene Name	RB1
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M
Calculated Molecular Weight	106159
Antigen Source	HUMAN
Antigen Region	227-256
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Dilution	WB: 1:2000 WB: 1:2000
Antigen Type	Synthetic Peptide

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 1/1/2026

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