DMPK Antibody (N-term)

Primary Antibodies; Neuroscience; Signal Transduction; Mitochondrion; Mitochondrion outer membrane

The protein encoded by this gene is a serine-threoninekinase that is closely related to other kinases that interact withmembers of the Rho family of small GTPases. Substrates for thisenzyme include myogenin, the beta-subunit of the L-type calciumchannels, and phospholemman. The 3' untranslated region of thisgene contains 5-37 copies of a CTG trinucleotide repeat. Expansionof this unstable motif to 5-5, copies causes myotonic dystrophytype I, which increases in severity with increasing repeat elementcopy number. Repeat expansion is associated with condensation oflocal chromatin structure that disrupts the expression of genes inthis region. Several alternatively spliced transcript variants ofthis gene have been described, but the full-length nature of someof these variants has not been determined.

RB36813

Affinity Purified Rabbit Polyclonal Antibody (Pab)

69385

11-39

WB: 1:1000