CD40 Antibody (C-term)

Crown Antibodies; Primary Antibodies; Cardiovascular; Immunology; Signal Transduction; Immunity; Toll-Like receptor signaling; Allograft rejection; Intestinal immune network for IgA production

The protein encoded by this gene is a member of theTNF-receptor superfamily. This receptor has been found to beessential in mediating a broad variety of immune and inflammatoryresponses including T cell-dependent immunoglobulin classswitching, memory B cell development, and germinal centerformation. AT-hook transcription factor AKNA is reported tocoordinately regulate the expression of this receptor and itsligand, which may be important for homotypic cell interactions.Adaptor protein TNFR2 interacts with this receptor and serves as amediator of the signal transduction. The interaction of thisreceptor and its ligand is found to be necessary foramyloid-beta-induced microglial activation, and thus is thought tobe an early event in Alzheimer disease pathogenesis. Twoalternatively spliced transcript variants of this gene encodingdistinct isoforms have been reported.

RB21158

Affinity Purified Rabbit Polyclonal Antibody (Pab)

Hs, M, Pig

HUMAN

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Synthetic Peptide