OPTN Antibody (Center)

Primary Antibodies; Immunology; Neuroscience; Signal Transduction; Autophagy

This gene encodes the coiled-coil containing proteinoptineurin. Optineurin may play a role in normal-tension glaucomaand adult-onset primary open angle glaucoma. Optineurin interactswith adenovirus E3-14.7K protein and may utilize tumor necrosisfactor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function incellular morphogenesis and membrane trafficking, vesicletrafficking, and transcription activation through its interactionswith the RAB8, huntingtin, and transcription factor IIIA proteins.Alternative splicing results in multiple transcript variantsencoding the same protein.

RB21453

Affinity Purified Rabbit Polyclonal Antibody (Pab)

Rat

HUMAN

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Synthetic Peptide

Optineurin, E3-147K-interacting protein, FIP-2, Huntingtin yeast partner L, Huntingtin-interacting protein 7, HIP-7, Huntingtin-interacting protein L, NEMO-related protein, Optic neuropathy-inducing protein, Transcription factor IIIA-interacting protein, TFIIIA-IntP, OPTN, FIP2, GLC1E, HIP7, HYPL, NRP