GNRHR Antibody (N-term)

Primary Antibodies; Antibody Collections; Neuroscience; GPCR Antibodies; Druggable G protein-coupled receptors (GPCRs)

This gene encodes the receptor for type 1gonadotropin-releasing hormone. This receptor is a member of theseven-transmembrane, G-protein coupled receptor (GPCR) family. Itis expressed on the surface of pituitary gonadotrope cells as wellas lymphocytes, breast, ovary, and prostate. Following binding ofgonadotropin-releasing hormone, the receptor associates withG-proteins that activate a phosphatidylinositol-calcium secondmessenger system. Activation of the receptor ultimately causes therelease of gonadotropic luteinizing hormone (LH) and folliclestimulating hormone (FSH). Defects in this gene are a cause ofhypogonadotropic hypogonadism (HH). Alternative splicing results inmultiple transcript variants encoding different isoforms. More than18 transcription initiation sites in the 5' region and multiplepolyA signals in the 3' region have been identified for this gene.

RB20076

Affinity Purified Rabbit Polyclonal Antibody (Pab)

37731

49-77

WB: 1:1000