CLCF1 Antibody (N-term)

Primary Antibodies; Immunology; Cytokine

This gene is a member of the glycoprotein (gp)13 cytokinefamily and encodes cardiotrophin-like cytokine factor 1 (CLCF1).CLCF1 forms a heterodimer complex with cytokine receptor-likefactor 1 (CRLF1). This dimer competes with ciliary neurotrophicfactor (CNTF) for binding to the ciliary neurotrophic factorreceptor (CNTFR) complex, and activates the Jak-STAT signalingcascade. CLCF1 can be actively secreted from cells by forming acomplex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is apotent neurotrophic factor, B-cell stimulatory agent andneuroendocrine modulator of pituitary corticotroph function.Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2).This syndrome is characterized by a profuse sweating after exposureto cold as well as congenital physical abnormalities of the headand spine. Alternative splicing results in multiple transcriptvariants encoding distinct isoforms.

RB38733

Affinity Purified Rabbit Polyclonal Antibody (Pab)

M

HUMAN

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Synthetic Peptide