CCR5 Antibody(Center)

NP_000570.1

This gene encodes a member of the beta chemokine receptor
family, which is predicted to be a seven transmembrane protein
similar to G protein-coupled receptors. This protein is expressed
by T cells and macrophages, and is known to be an important
co-receptor for macrophage-tropic virus, including HIV, to enter
host cells. Defective alleles of this gene have been associated
with the HIV infection resistance. The ligands of this receptor
include monocyte chemoattractant protein 2 (MCP-2), macrophage
inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory
protein 1 beta (MIP-1 beta) and regulated on activation normal T
expressed and secreted protein (RANTES). Expression of this gene
was also detected in a promyeloblastic cell line, suggesting that
this protein may play a role in granulocyte lineage proliferation
and differentiation. This gene is located at the chemokine receptor
gene cluster region. Two transcript variants encoding the same
protein have been found for this gene.

1234

H

151-177

This CCR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-177 amino acids from the Central region of human CCR5.