CCR5 Antibody(Center)

Primary Antibodies; Antibody Collections; Cancer; Cardiovascular; Immunology; Microbiology; Neuroscience; Signal Transduction; GPCR Antibodies; Druggable G protein-coupled receptors (GPCRs); Host cell receptor for virus entry; Host-virus interaction; Immune system process; Chemokine receptor family; Chemokine signaling; Inflammation mediated by chemokine and cytokine signaling

This gene encodes a member of the beta chemokine receptorfamily, which is predicted to be a seven transmembrane proteinsimilar to G protein-coupled receptors. This protein is expressedby T cells and macrophages, and is known to be an importantco-receptor for macrophage-tropic virus, including HIV, to enterhost cells. Defective alleles of this gene have been associatedwith the HIV infection resistance. The ligands of this receptorinclude monocyte chemoattractant protein 2 (MCP-2), macrophageinflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatoryprotein 1 beta (MIP-1 beta) and regulated on activation normal Texpressed and secreted protein (RANTES). Expression of this genewas also detected in a promyeloblastic cell line, suggesting thatthis protein may play a role in granulocyte lineage proliferationand differentiation. This gene is located at the chemokine receptorgene cluster region. Two transcript variants encoding the sameprotein have been found for this gene.

RB41438

Affinity Purified Rabbit Polyclonal Antibody (Pab)

40524

151-177

WB: 1:1000