NFKB1 Antibody (S932)

Primary Antibodies; Cancer; Cell Biology; Immunology; Signal Transduction; Inflammasome; RIG-l-like Receptor; Toll receptor signaling; Toll-Like Receptor; Toll-Like receptor signaling; B cell receptor signaling; T cell activation; T cell receptor signaling; Chemokine signaling; Inflammation mediated by chemokine and cytokine signaling; Apoptosis; Apoptosis signaling

NFKB1 is a 15 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 5 kD protein. The 15 kD protein is a Rel protein-specific transcription inhibitor and the 5 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth.

RB11204

Affinity Purified Rabbit Polyclonal Antibody (Pab)

C, M

HUMAN

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Synthetic Peptide