STAT3 Antibody (C-term)

Primary Antibodies; Cancer; Cardiovascular; Developmental Biology; Microbiology; Signal Transduction; Viral process; Host-virus interaction; Chemokine signaling; Inflammation mediated by chemokine and cytokine signaling; Interleukin signaling; JAK-STAT signaling; Jak-STAT signaling KEGG

The protein encoded by this gene is a member of the STATprotein family. In response to cytokines and growth factors, STATfamily members are phosphorylated by the receptor associatedkinases, and then form homo- or heterodimers that translocate tothe cell nucleus where they act as transcription activators. Thisprotein is activated through phosphorylation in response to variouscytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety ofgenes in response to cell stimuli, and thus plays a key role inmany cellular processes such as cell growth and apoptosis. Thesmall GTPase Rac1 has been shown to bind and regulate the activityof this protein. PIAS3 protein is a specific inhibitor of thisprotein. Three alternatively spliced transcript variants encodingdistinct isoforms have been described.

RB41075

Affinity Purified Rabbit Polyclonal Antibody (Pab)

B, M, Pig, Rat

HUMAN

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Synthetic Peptide