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HUMAN-SHB(Y268) Antibody

HUMAN-SHB(Y268) Antibody

Item no.	ABC-AP20620a
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB, FC, IHC-P
Specific against	other
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	SHB, SH2 domain-containing adapter protein B
Available
Primary Accession	Q15464
Application	IHC-P, FC, WB
Bio Background	Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
Bio References	Welsh M., et al.Oncogene 9:19-27(1994). Humphray S.J., et al.Nature 429:369-374(2004). Mural R.J., et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. Karlsson T., et al.Oncogene 10:1475-1483(1995). Karlsson T., et al.Oncogene 13:955-961(1996).
Clonality	Polyclonal
Clone/Animal Names	RB47168
Gene ID	6461
Gene Name	SHB
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of lysates from HepG2, Jurkat, K562, HUVEC cell line (from left to right), using SHB-Y268 Antibody(Cat. #AP20620a). AP20620a was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Immunohistochemical analysis of paraffin-embedded H. small intestine section using Phospho-HUMAN-SHB(Y268). ctrl(Cat#AP20620a). AP20620a was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
Type image 2	IHC-P
Dilution image 2	1:25
Legend image 3	Flow cytometric analysis of HepG2 cells using Phospho-HUMAN-SHB(Y268). ctrl(green, Cat#AP20620a) compared to an isotype control of rabbit IgG(blue). AP20620a was diluted at 1:25 dilution. An Alexa Fluor® 488 goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody.
Type image 3	FC
Dilution image 3	1:25
Isotype	Rabbit IgG
Calculated MW	55042
Antigen Source	HUMAN
Target/Specificity	This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 250-290 amino acids from human.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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ABC-AP20620a-datasheet.pdf

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Amount: 400 ul

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Delivery expected until 10/2/2025

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