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(Mouse) Trim24 Antibody (C-term)

(Mouse) Trim24 Antibody (C-term)

Item no.	ABC-AP20896c-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Oncology Neuroscience Aging & Neurological Disorders Antibodies Carcinoma Cell Biology Cell Status Immunohistochemistry Western Blot Immunofluorescence Autophagy Primary Antibodies
Type	Antibody Polyclonal
Applications	Immunofluorescence, Western Blot, Immunohistochemistry
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Transcription intermediary factor 1-alpha, TIF1-alpha, 632-, E3 ubiquitin-protein ligase Trim24, Tripartite motif-containing protein 24, Trim24, Tif1, Tif1a
Available
Primary Accession	Q64127
Bio Background	Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac) (By similarity). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis via its effects on p53/TP53 levels. Up-regulates ligand- dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, such as RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes. Required for normal transition from proliferating neonatal hepatocytes to quiescent adult hepatocytes.
Bio References	le Douarin B., et al.EMBO J. 14:2020-2033(1995). le Douarin B., et al.EMBO J. 15:6701-6715(1996). Zhong S., et al.Nat. Genet. 23:287-295(1999). Seeler J.-S., et al.Mol. Cell. Biol. 21:3314-3324(2001). Torres-Padilla M.E., et al.J. Cell Biol. 174:329-338(2006).
Gene ID	21848
Gene Name	Trim24
Reactivity	M
Calculated MW	116657
Antigen Source	HUMAN
Target/Specificity	This Mouse Trim24 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 789-843 amino acids from the C-terminal region of Mouse Trim24.

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Amount: 80 ul

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