Mouse Epha1 Antibody (N-term)

Q60750

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.

Polyclonal

13835

Purified Rabbit Polyclonal Antibody (Pab)

Western blot analysis of lysates from mouse kidney, mouse lung, mouse skin tissue (from left to right), using Epha1 Antibody (N-term)(Cat. #AP20929b). AP20929b was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.

1:1000

108578

This Mouse Epha1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 70-105 amino acids from the N-terminal region of Mouse Epha1.