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Mouse Rad9a Antibody (C-term)

Mouse Rad9a Antibody (C-term)

Item no.	ABC-AP21265b-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Antibodies Western Blot Primary Antibodies
Type	Antibody Polyclonal
Applications	Western Blot
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Cell cycle checkpoint control protein RAD9A, mRAD9, DNA repair exonuclease rad9 homolog A, Rad9-like protein, Rad9a, Rad9
Available
Primary Accession	Q9Z0F6
Bio Background	Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity (By similarity).
Bio References	Hang H., et al.J. Cell. Physiol. 177:241-247(1998). Carninci P., et al.Science 309:1559-1563(2005). Park Y.-G., et al.Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases. Ishii H., et al.Proc. Natl. Acad. Sci. U.S.A. 102:9655-9660(2005). Sweet S.M., et al.Mol. Cell. Proteomics 8:904-912(2009).
Gene ID	19367
Gene Name	Rad9a
Reactivity	H, M
Calculated MW	42059
Antigen Source	HUMAN
Target/Specificity	This Mouse Rad9a antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 279-313 amino acids from the C-terminal region of Mouse Rad9a.

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Amount: 80 ul

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