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Mouse Jarid2 Antibody (Center)

Mouse Jarid2 Antibody (Center)

Item no.	ABC-AP21417c-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Antibodies Western Blot Primary Antibodies
Type	Antibody Polyclonal
Applications	Western Blot
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Protein Jumonji, Jumonji/ARID domain-containing protein 2, Jarid2, Jmj
Available
Primary Accession	Q62315
Bio Background	Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.
Bio References	Takeuchi T., et al.Genes Dev. 9:1211-1222(1995). Carninci P., et al.Science 309:1559-1563(2005). Mural R.J., et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. Motoyama J., et al.Mech. Dev. 66:27-37(1997). Takeuchi T., et al.Mech. Dev. 86:29-38(1999).
Gene ID	16468
Gene Name	Jarid2
Reactivity	M
Calculated MW	137445
Antigen Source	HUMAN
Target/Specificity	This Mouse Jarid2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 435-468 amino acids from the Central region of Mouse Jarid2.

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Amount: 80 ul

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