Comparison

Androgen Receptor (ANDR) Antibody

Item no. ABC-AP2509A-ev
Manufacturer Abcepta
Amount 80 ul
Category
Type Antibody Primary
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications WB, IHC-P
Specific against other
Host Rabbit
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Similar products AR, Androgen receptor, DHTR, NR3C4, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4
Available
Primary Accession
P10275
Antigen Type
Synthetic Peptide
Application
IHC-P, WB
Bio Background
Androgen receptor (ANDR) has 3 major functional domains: the N-terminal domain, DNA-binding domain, and an androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The gene for this protein contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of the protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations are also associated with complete androgen insensitivity (CAIS). PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor; sumoylation of ANDR represses androgen receptor dependent transcription.
Bio References
Nishida, et al. J. Biol. Chem. 277 (44), 41311-41317 (2002)
Sills, E.S., et al., Int. J. Mol. Med. 9(1):45-48 (2002).
Chavez, B., et al., J. Hum. Genet. 46(10):560-565 (2001).
Ahmed, S.F., et al., J. Clin. Endocrinol. Metab. 85(2):658-665 (2000).
Marcelli, M., et al., Cancer Res. 60(4):944-949 (2000).
Clonality
Polyclonal
Clone/Animal Names
RB2579
Gene ID
367
Gene Name
AR
Subtitle
Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity
H, M
Legend image 1
ANDR (Cat. #AP2509a) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the AR antibody detected the AR protein (arrow).
Type image 1
WB
Dilution image 1
1:1000
Legend image 2
ANDR Antibody (Sumo-site) (Cat. #AP2509a) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the ANDR antibody detected the ANDR protein (arrow).
Type image 2
WB
Dilution image 2
1:1000
Legend image 3
Androgen Receptor Antibody (ANDR) (Cat. #AP2509a)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Androgen Receptor Antibody (ANDR) for immunohistochemistry. Clinical relevance has not been evaluated.
Type image 3
IHC-P
Dilution image 3
1:10~50
Other Accession
Q9GKL7; P19091; O97952; Q5JUN9
Predicted
Pr, Pig
Isotype
Rabbit Ig
Calculated MW
99188
Antigen Region
365-392
Antigen Source
HUMAN
Target/Specificity
This Androgen Receptor (ANDR) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 365-392 amino acids from human Androgen Receptor (ANDR).
NCBI Accession
NP_000035.2; NP_001011645.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 80 ul
Available: In stock
available

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