« Back
Home /
Phospho-Rb(S780) Antibody

Phospho-Rb(S780) Antibody

Item no.	ABC-AP3237a
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Immunohistochemistry Western Blot Primary Antibodies Dot Blot
Type	Antibody Polyclonal
Applications	WB, IHC-P, Dot
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Citations	Wagner, S., et al., Biochem. Pharmacol. 69(7):1059-1067 (2005). Roesch, A., et al., Mod. Pathol. 18(4):565-572 (2005). Lieman, J.H., et al., J. Biol. Chem. 280(11):10484-10490 (2005). Budde, A., et al., Oncogene 24(10):1802-1808 (2005). Zapata, E., et al., FEBS J. 272(6):1343-1353 (2005).
NCBI	NP_000312.2
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Retinoblastoma-associated protein,p105-Rb,pRb,Rb,pp110,RB1
Similar products	Rb, RB1, Retinoblastoma-associated protein, p105-Rb, pRb, pp110
Available
Manufacturer - Category	Primary Antibodies; Antibody Collections; Cancer; Cell Biology; Phospho Antibodies; Viral process; Host-virus interaction
Manufacturer - Targets	This Rb Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S780 of human Rb.
Bio Background	RB1 likely acts as a regulator of other genes. It forms a complex with adenovirus E1A and with SV4 large T antigen, acts as a tumor suppressor, and may bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. RB1 is a potent inhibitor of E2F-mediated trans-activation, and also recruits and targets histone methyltransferase SUV39H1 leading to epigenetic transcriptional repression. This protein inhibits the intrinsic kinase activity of TAF1. Defects in RB1 are the cause of childhood cancer retinoblastoma (RB), a congenital malignant tumor that arises from the nuclear layers of the retina. Defects in RB1 are also a cause of bladder cancer and osteogenic sarcoma.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB7663
Gene Name	RB1
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Predicted Reactivity	M, Rat
Calculated Molecular Weight	106159
Antigen Source	HUMAN
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Dilution	IHC-P: 1:50~100 DB: 1:500
Antigen Type	Synthetic Peptide

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

ABC-AP3237a-datasheet.pdf

Request safety datasheet

Simple Order Order Subscription

Amount: 400 ul

available

Delivery expected until 1/1/2026

Express Delivery: Save 16 days

Compare

Add to wishlist

Get an offer