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Phospho-STAT5a(S726) Antibody

Phospho-STAT5a(S726) Antibody

Item no.	ABC-AP3266a-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Oncology Neuroscience Targets for Rodent Neurosciences Antibodies Hematology Leukemia Lymphoma Immunohistochemistry Western Blot Primary Antibodies Dot Blot
Type	Antibody Polyclonal
Applications	Western Blot, Dot blot, Immunohistochemistry
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Signal transducer and activator of transcription 5A, STAT5A, STAT5
Available
Primary Accession	P42229
Other Accession	Q9TUZ0; P51692; Q9TUM3; Q9TUZ1; Q95115; P42231
Antigen Type	Synthetic Peptide
Bio Background	STAT5a is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this protein is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this protein in cells.
Bio References	Martens, N., et al., J. Biol. Chem. 280(14):13817-13823 (2005). Defilippi, P., et al., J. Cell Biol. 168(7):1099-1108 (2005). Sekine, Y., et al., J. Biol. Chem. 280(9):8188-8196 (2005). Sultan, A.S., et al., Oncogene 24(5):746-760 (2005). Moriggl, R., et al., Cancer Cell 7(1):87-99 (2005).
Gene ID	6776
Gene Name	STAT5A
Reactivity	H
Predicted	B, Pig, Sh
Calculated MW	90647
Antigen Source	HUMAN
Target/Specificity	This STAT5a Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S726 of human STAT5a.
NCBI Accession	NP_003143.2

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Amount: 80 ul

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