Phospho-STAT5a(S726) Antibody

Primary Antibodies; Antibody Collections; Cancer; Cardiovascular; Cell Biology; Metabolism; Signal Transduction; Phospho Antibodies; Catalog Updated; Interleukin signaling; JAK-STAT signaling; Jak-STAT signaling KEGG

STAT5a is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this protein is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this protein in cells.

RB5945

Affinity Purified Rabbit Polyclonal Antibody (Pab)

B, Pig, Sh

HUMAN

WB: 1:1000
IHC-P: 1:50~100
DB: 1:500