« Back
Home /
Phospho-HSPB1(S78) Antibody

Phospho-HSPB1(S78) Antibody

Item no.	ABC-AP3347a
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB, Dot
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	HSPB1, HSP27, HSP28, Heat shock protein beta-1, 28 kDa heat shock protein, Estrogen-regulated 24 kDa protein, Heat shock 27 kDa protein, Stress-responsive protein 27, HspB1, HSP 27, SRP27
Available
Primary Accession	P04792
Antigen Type	Synthetic Peptide
Application	DB, WB
Bio Background	In response to adverse changes in their environment, cells from many organisms increase the expression of a class of proteins referred to as heat shock or stress proteins. HSBP1 exhibits rapid increased phosphorylation in response to various mitogens, tumor promoters (e.g. phorbol esters) and calcium ionophores, and high levels are associated with carcinoma of the breast and with endometrial adenocarcinomas. Heat shock of HeLa cell cultures, or treatment with arsenite, phorbol ester, or tumor necrosis factor, causes a rapid phosphorylation of preexisting HSBP1, with Ser82 as the major site and Ser78 the minor site of phosphorylation. HSBP1 may exert phosphorylation-activated functions linked with growth signaling pathways in unstressed cells. A homeostatic function at this level could protect cells from adverse effects of signal transduction systems which may be activated inappropriately during stress.
Bio References	Wano, C., et al., Exp. Cell Res. 298(2):584-592 (2004). Evgrafov, O.V., et al., Nat. Genet. 36(6):602-606 (2004). Song, H., et al., Biochem. Biophys. Res. Commun. 314(1):143-150 (2004). Chauhan, D., et al., Blood 102(9):3379-3386 (2003). Van Why, S.K., et al., J. Am. Soc. Nephrol. 14(1):98-106 (2003).
Clonality	Polyclonal
Clone/Animal Names	RB11379
Gene ID	3315
Gene Name	HSPB1
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of lysates from Hela cell line, untreated or treated with UV, 2 hours, using HSPB1 Antibody(RB56433)(upper) or Tubulin (lower).
Type image 1	WB
Dilution image 1	1:500
Legend image 2	Dot blot analysis of Phospho-HSBP1-S78 polyclonal antibody (Cat# AP3347a) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentration was 0.5ug per ml. P-Pab: phospho-antibody; P-Peptide: phospho-peptide; NP-Peptide: non-phospho-peptide.
Type image 2	DB
Dilution image 2	1:500
Isotype	Rabbit Ig
Calculated MW	22783
Antigen Source	HUMAN
Target/Specificity	This HSPB1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S78 of human HSPB1.
NCBI Accession	NP_001531.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

ABC-AP3347a-datasheet.pdf

Request safety datasheet

Simple Order Order Subscription

Amount: 400 ul

available

Delivery expected until 9/4/2025

Express Delivery: Save 1 days

Compare

Add to wishlist

Get an offer