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Phospho-FRAP1(T2446) Antibody

Phospho-FRAP1(T2446) Antibody

Manufacturer	Abcepta
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Specific against	other
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	Dot
Amount	80 ul
Host	Rabbit
Item no.	ABC-AP3433a-ev
eClass 6.1	32160702
eClass 9.0	32160702
Available
Primary Accession	P42345
Antigen Type	Synthetic Peptide
Application	DB
Bio Background	FRAP1 belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. FRAP1 is a part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.
Bio References	Dowling, R.J., Cancer Res. 67 (22), 10804-10812 (2007) Bai, X., Science 318 (5852), 977-980 (2007) Zhou, J., Proc. Natl. Acad. Sci. U.S.A. 104 (41), 16158-16163 (2007) Radulovic, S., J BUON 12 SUPPL 1, S151-S162 (2007)
Clonality	Polyclonal
Clone/Animal Names	RB13089
Gene ID	2475
Gene Name	MTOR
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Dot blot analysis of anti-FRAP1-pT2446 Phospho-specific Pab (Cat.AP3433a) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.
Type image 1	DB
Dilution image 1	1:500
Other Accession	P42346; Q9JLN9
Predicted	M, Rat
Isotype	Rabbit IgG
Calculated MW	288892
Antigen Source	HUMAN
Target/Specificity	This FRAP1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T2446 of human FRAP1.
NCBI Accession	NP_004949.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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ABC-AP3433a-ev-datasheet.pdf

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Amount: 80 ul

available

Delivery expected until 7/5/2024