Phospho-MAPK8(T183) Antibody

Primary Antibodies; Antibody Collections; Cancer; Immunology; Neuroscience; Signal Transduction; Phospho Antibodies; Anti-Wnt-Pathway (plus Lgr5) Antibodies; RIG-l-like Receptor; Toll receptor signaling; Toll-Like Receptor; Toll-Like receptor signaling; T cell activation; Interferon-gamma signaling; Apoptosis signaling

MAPK8 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation.

RB13240

Affinity Purified Rabbit Polyclonal Antibody (Pab)

M, Rat, X

HUMAN

DB: 1:500