Phospho-RAF1(S494) Antibody

Primary Antibodies; Antibody Collections; Cancer; Cell Biology; Metabolism; Signal Transduction; Phospho Antibodies; B cell receptor signaling; Fc gamma R-mediated phagocytosis; T cell activation; T cell receptor signaling; Chemokine signaling; Inflammation mediated by chemokine and cytokine signaling; Interleukin signaling; Mitochondrion

Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration.

RB13292

Affinity Purified Rabbit Polyclonal Antibody (Pab)

B, C, M, Rat

HUMAN

DB: 1:500