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Phospho-TSC1(S505) Antibody

Phospho-TSC1(S505) Antibody

Item no.	ABC-AP3470a
Manufacturer	Abcepta
Amount	400 ul
Category	Oncology Antibodies By Cell Type Carcinoma Hematology Lymphoma Myeloma Adenocarcinoma Primary Antibodies Astrocytoma Dot Blot
Type	Antibody Polyclonal
Applications	Dot
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Citations	Wu, J., et al., J. Cutan. Pathol. 31(5):383-387 (2004). Lewis, J.C., et al., J. Med. Genet. 41(3):203-207 (2004). J, et al., J. Child Neurol. 19(2):102-106 (2004). Murthy, V., et al., J. Biol. Chem. 279(2):1351-1358 (2004). Astrinidis, A., et al., J. Biol. Chem. 278(51):51372-51379 (2003).
NCBI	NP_000359.1,NP_001155898.1,NP_001155899.1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Hamartin,Tuberous sclerosis 1 protein,TSC1,KIAA0243,TSC
Similar products	Hamartin, TSC1, KIAA0243, TSC, Tuberous sclerosis 1 protein
Available
Manufacturer - Category	Primary Antibodies; Antibody Collections; Cancer; Cell Biology; Metabolism; Phospho Antibodies
Manufacturer - Targets	This TSC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S505 of human TSC1.
Bio Background	TSC1 is implicated as a tumor suppressor, and may have a function in vesicular transport. Interaction between TSC1 and TSC2 may facilitate vesicular docking.Defects in TSC1 are the cause of tuberous sclerosis complex (TSC). The molecular basis of TSC is a functional impairement of the hamartin-tuberin complex. TSC is an autosomal dominant multi-system disorder that affects especially the brain, kidneys, heart, and skin. Defects in TSC1 may be a cause of focal cortical dysplasia of Taylor balloon cell type (FCDBC). FCDBC is a subtype of cortical displasias linked to chronic intractable epilepsy. Cortical dysplasias display a broad spectrum of structural changes, which appear to result from changes in proliferation, migration, differentiation, and apoptosis of neuronal precursors and neurons during cortical development.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB13337
Gene Name	TSC1 {ECO:0000303\|PubMed:9242607, ECO:0000312\|HGNC:HGNC:12362}
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Predicted Reactivity	M
Calculated Molecular Weight	129767
Antigen Source	HUMAN
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Dilution	DB: 1:500
Antigen Type	Synthetic Peptide

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 1/1/2026

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