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Phospho-TSC2(S1420) Antibody

Phospho-TSC2(S1420) Antibody

Item no.	ABC-AP3480a
Manufacturer	Abcepta
Amount	400 ul
Category	Oncology Antibodies By Cell Type Carcinoma Hematology Lymphoma Myeloma Immunofluorescence Primary Antibodies Astrocytoma Dot Blot
Type	Antibody Polyclonal
Applications	IF, Dot
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Citations	Li, Y., et al., Mol. Cell. Biol. 24(18):7965-7975 (2004). Karbowniczek, M., et al., J. Biol. Chem. 279(29):29930-29937 (2004). Corradetti, M.N., et al., Genes Dev. 18(13):1533-1538 (2004). Birchenall-Roberts, M.C., et al., J. Biol. Chem. 279(24):25605-25613 (2004). Lewis, J.C., et al., J. Med. Genet. 41(3):203-207 (2004).
NCBI	NP_000539.2,NP_001070651.1,NP_001107854.1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Tuberin,Tuberous sclerosis 2 protein,TSC2,TSC4
Similar products	TSC2, TSC4, Tuberin, Tuberous sclerosis 2 protein
Available
Manufacturer - Category	Primary Antibodies; Antibody Collections; Cell Biology; Metabolism; Signal Transduction; Phospho Antibodies; Viral process; Host-virus interaction
Manufacturer - Targets	This TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1420 of human TSC2.
Bio Background	Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB13391
Gene Name	TSC2 {ECO:0000303\|PubMed:7558029, ECO:0000312\|HGNC:HGNC:12363}
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Calculated Molecular Weight	200608
Antigen Source	HUMAN
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Dilution	IF: 1:10~50 DB: 1:500
Antigen Type	Synthetic Peptide

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 1/1/2026

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