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Phospho-E2F1(S332) Antibody

Phospho-E2F1(S332) Antibody

Item no.	ABC-AP3485a-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Oncology Antibodies Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Cell Biology Cell Status Senescence Primary Antibodies Astrocytoma Bladder Cancer Bone Cancer Dot Blot
Type	Antibody Polyclonal
Applications	Dot blot
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Transcription factor E2F1, E2F-1, PBR3, Retinoblastoma-associated protein 1, RBAP-1, Retinoblastoma-binding protein 3, RBBP-3, pRB-binding protein E2F-1, E2F1, RBBP3
Available
Primary Accession	Q01094
Antigen Type	Synthetic Peptide
Bio Background	E2F1 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
Bio References	O'Donnell, K.A., et al., Nature 435(7043):839-843 (2005). Wang, C., et al., J. Biol. Chem. 280(13):12339-12343 (2005). Joshi, B., et al., Oncogene 24(13):2204-2217 (2005). Saberwal, G., et al., Int. J. Hematol. 80(2):146-154 (2004). Chaussepied, M., et al., Mol. Cell 16(5):831-837 (2004).
Gene ID	1869
Gene Name	E2F1
Reactivity	H
Calculated MW	46920
Antigen Source	HUMAN
Target/Specificity	This E2F1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S332 of human E2F1.
NCBI Accession	NP_005216.1

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Amount: 80 ul

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