Cleaved-CASP3 (Asp175) Antibody

Item no.	ABC-AP3725a
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Immunohistochemistry Primary Antibodies Dot Blot
Type	Antibody Polyclonal
Applications	IHC-P, Dot
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Citations	Mei, Y., et al. Mol. Cell 37(5):668-678(2010) Sohn, E.J., et al. Cancer Res. 70(3):1154-1163(2010) Karamitopoulou, E., et al. Pathology 42(1):37-42(2010)
NCBI	NP_004337.2,NP_116786.1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Caspase-3,CASP-3,Apopain,Cysteine protease CPP32,CPP-32,Protein Yama,SREBP cleavage activity 1,SCA-1,Caspase-3 subunit p17,Caspase-3 subunit p12,CASP3,CPP32
Similar products	CASP3, CPP32, Caspase-3, Apopain, Cysteine protease CPP32, Protein Yama, SREBP cleavage activity 1, Caspase-3 subunit p17, Caspase-3 subunit p12, CASP-3, CPP-32, SCA-1
Available
Manufacturer - Category	Primary Antibodies; Antibody Collections; Cancer; Cell Biology; Metabolism; Neuroscience; Amyotrophic Lateral Sclerosis (ALS); Apoptosis; Apoptosis signaling
Manufacturer - Targets	This Cleaved antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-175 amino acids from human Cleaved.
Bio Background	CASP3 encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 1. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB25833
Gene Name	CASP3
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Predicted Reactivity	B, M, Pig, Rat
Calculated Molecular Weight	31608
Antigen Source	HUMAN
Antigen Region	149-175
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Dilution	IHC-P: 1:50~100 DB: 1:500
Antigen Type	Synthetic Peptide

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

ABC-AP3725a-datasheet.pdf

Request safety datasheet

Simple Order Order Subscription

Amount: 400 ul

available

Delivery expected until 1/1/2026

Express Delivery: Save 16 days

Compare

Add to wishlist

Get an offer