Bi-Phospho-JNK1(T183/Y185) Antibody

P49187; Q61831; P53779; Q8QHK8; P49185; Q91Y86; NP_620634.1; NP_620637.1; NP_002741.1; NP_620635.1

The protein encoded by this gene is a member of the MAP
kinase family. MAP kinases act as an integration point for multiple
biochemical signals, and are involved in a wide variety of cellular
processes such as proliferation, differentiation, transcription
regulation and development. This kinase is activated by various
cell stimuli, and targets specific transcription factors, and thus
mediates immediate-early gene expression in response to cell
stimuli. The activation of this kinase by tumor-necrosis factor
alpha (TNF-alpha) is found to be required for TNF-alpha induced
apoptosis. This kinase is also involved in UV radiation induced
apoptosis, which is thought to be related to cytochrom c-mediated
cell death pathway. Studies of the mouse counterpart of this gene
suggested that this kinase play a key role in T cell proliferation,
apoptosis and differentiation. Four alternatively spliced
transcript variants encoding distinct isoforms have been reported.

5599

H

48296

This JNK1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T183/Y185 of human JNK1.