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Phospho-PARP1(S177) Antibody

Phospho-PARP1(S177) Antibody

Item no.	ABC-AP3786a
Manufacturer	Abcepta
Amount	400 ul
Category	Oncology Antibodies By Cell Type Carcinoma Hematology Lymphoma Melanoma Sarcoma Primary Antibodies Dot Blot
Type	Antibody Polyclonal
Applications	Dot
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Citations	Majewski, P.M., et al. J. Biol. Chem. 285(45):34828-34838(2010) Kim, M., et al. Cancer Sci. 101(11):2436-2442(2010) Dong, Y., et al. Cancer Res. 70(20):8088-8096(2010) Krishnakumar, R., et al. Mol. Cell 39(5):736-749(2010) Lee, K.A., et al. Rheumatol. Int. (2010) In press :
NCBI	NP_001609.2
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Poly [ADP-ribose] polymerase 1,PARP-1,ADP-ribosyltransferase diphtheria toxin-like 1,ARTD1,NAD(+) ADP-ribosyltransferase 1,ADPRT 1,Poly[ADP-ribose] synthase 1,PARP1,ADPRT,PPOL
Similar products	PARP1, PARP-1, PPOL, ADPRT, NAD(+) ADP-ribosyltransferase 1, Poly [ADP-ribose] polymerase 1, ADPRT 1, Poly[ADP-ribose] synthase 1, ARTD1, ADP-ribosyltransferase diphtheria toxin-like 1
Available
Manufacturer - Category	Primary Antibodies; Antibody Collections; Cell Biology; Metabolism; Phospho Antibodies
Manufacturer - Targets	This PARP1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S177 of human PARP1.
Bio Background	This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclearproteins by poly(ADP-ribosyl)ation. The modification is dependenton DNA and is involved in the regulation of various importantcellular processes such as differentiation, proliferation, andtumor transformation and also in the regulation of the molecularevents involved in the recovery of cell from DNA damage. Inaddition, this enzyme may be the site of mutation in Fanconianemia, and may participate in the pathophysiology of type Idiabetes.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB40143
Gene Name	PARP1 {ECO:0000303\|PubMed:21680843, ECO:0000312\|HGNC:HGNC:270}
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Predicted Reactivity	Ha, M, Rat
Calculated Molecular Weight	113084
Antigen Source	HUMAN
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Dilution	DB: 1:500
Antigen Type	Synthetic Peptide

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 1/1/2026

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