Phospho-PTEN(S385) Antibody

Primary Antibodies; Antibody Collections; Cancer; Cell Biology; Metabolism; Signal Transduction; Phospho Antibodies; Inflammation mediated by chemokine and cytokine signaling

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.

RB39440

Affinity Purified Rabbit Polyclonal Antibody (Pab)

M, Rat, X

HUMAN

DB: 1:500