Phospho-mouse IKKB(S701) Antibody

Primary Antibodies; Antibody Collections; Cardiovascular; Cell Biology; Immunology; Signal Transduction; Phospho Antibodies

NFKB1 (MIM 16411) or NFKB2 (MIM 16412) is bound to REL(MIM 16491), RELA (MIM 16414), or RELB (MIM 64758) to form theNFKB complex. The NFKB complex is inhibited by I-kappa-B proteins(NFKBIA, MIM 1648, or NFKBIB, MIM 64495), which inactivateNF-kappa-B by trapping it in the cytoplasm. Phosphorylation ofserine residues on the I-kappa-B proteins by kinases (IKBKA, MIM6664, or IKBKB) marks them for destruction via the ubiquitinationpathway, thereby allowing activation of the NF-kappa-B complex.Activated NFKB complex translocates into the nucleus and binds DNAat kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or Gpurine; and Y is a C or T pyrimidine).

RB40105

Affinity Purified Rabbit Polyclonal Antibody (Pab)

86690

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Synthetic Peptide