CHEK2 Antibody (N-term)

Crown Antibodies; Primary Antibodies; Cancer; SARS-Human interaction partners

CHEK2 is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53.

RB19067

Affinity Purified Rabbit Polyclonal Antibody (Pab)

60915

111-141

IF: 1:10~50
WB: 1:1000
WB: 1:1000
IHC-P: 1:50~100
FC: 1:10~50