S100B Antibody

Primary Antibodies; Cell Biology; Signal Transduction

S1B is a member of the S1 family of proteins containing 2 EF-hand calcium-binding motifs. S1 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S1 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.

RB22934

Affinity Purified Rabbit Polyclonal Antibody (Pab)

Rb

HUMAN

WB: 1:1000
WB: 1:2000
WB: 1:2000
IHC-P-Leica: 1:500
IHC-P-Leica: 1:500