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XBP1 Antibody (Center)

XBP1 Antibody (Center)

Item no.	ABC-AP5088C-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Antibodies Flow Cytometry Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Polyclonal
Applications	Western Blot, Flow cytometry, Immunohistochemistry
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	X-box-binding protein 1, XBP-1, Tax-responsive element-binding protein 5, XBP1, TREB5, XBP2
Available
Primary Accession	P17861
Other Accession	Q9R1S4; O35426; Q3SZZ2
Antigen Type	Synthetic Peptide
Bio Background	XBP1 encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor.
Bio References	Navon, A., et al. FEBS Lett. 584(1):67-73(2010) Guan, D., et al. Mol. Carcinog. 49(1):68-74(2010) del Pozo, N., et al. Hum. Immunol. 70(11):950-952(2009)
Gene ID	7494
Gene Name	XBP1 (HGNC:12801)
Reactivity	H
Predicted	B, M, Rat
Calculated MW	28695
Antigen Region	62-91
Antigen Source	HUMAN
Target/Specificity	This XBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-91 amino acids from the Central region of human XBP1.
NCBI Accession	NP_001073007.1; NP_005071.2

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Amount: 80 ul

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