ACE2 (NCOVID/SARS Receptor) Antibody (C-term)

Primary Antibodies; Cardiovascular; Cell Biology; ACE2 receptors; Host cell receptor for virus entry; Viral entry into host cell; Host-virus interaction; SARS-Human interactions; SARS-Human interaction partners

ACE2 cDNA encodes a deduced 85-amino acid protein containing a potential 17-amino acid N-terminal signal peptide and a putative 22-amino acid C-terminal membrane anchor. It also possesses a zinc metalloprotease consensus sequence and a conserved glutamine residue that may function as a third zinc ligand. ACE2 is expressed predominantly in vascular endothelial cells of the heart and kidney. ACE converts angiotensin I to angiotensin II, ACE2 converts angiotensin I to angiotensin 1-9, which has 9 amino acids. Angiotensin II is a potent blood vessel constrictor, while angiotensin 1-9 does not impact blood vessels but is cleaved by ACE to a shorter peptide, angiotensin 1-7, which is a blood vessel dilator. Spike (S) proteins of coronaviruses, including the SARS coronavirus, bind with cellular receptors to mediate infection of target cells. ACE2 binds the S1 domain of the SARS coronavirus S protein. SARS coronavirus replicates efficiently on ACE2-transfected but not mock-transfected 293T cells. Anti-ACE2 but not anti-ACE1 antibody blocks viral replication on Vero E6 cells. It has been proposed that ACE2 is a functional receptor for SARS coronavirus.

RB4819

Purified Rabbit Polyclonal Antibody (Pab)

92463

773-805

WB: 1:1000
WB: 1:1000
IHC-P: 1:50~100
IHC-P: 1:50~100

Angiotensin-converting enzyme 2, ACE-related carboxypeptidase, Angiotensin-converting enzyme homolog, ACEH, Metalloprotease MPROT15, Processed angiotensin-converting enzyme 2, ACE2, Coronavirus receptor, COVID receptor, SARS reeptor, COVID-19 Receptor, COVID19 receptor