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BACE2 Antibody (Center)

BACE2 Antibody (Center)

Item no.	ABC-AP6121a
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applications	WB, FC
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	BACE2, AEPLC, ALP56, ASP21, Beta-secretase 2, Aspartic-like protease 56 kDa, Aspartyl protease 1, Beta-site amyloid precursor protein cleaving enzyme 2, Down region aspartic protease, Memapsin-1, Membrane-associated aspartic protease 1, Theta-secretase, ASP1, DRAP, Asp 1, Beta-site APP cleaving enzyme 2
Available
Primary Accession	Q9Y5Z0
Antigen Type	Synthetic Peptide
Application	WB, FC
Bio Background	Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by BACE2. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease.
Bio References	Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003). Basi, G., et al., J. Biol. Chem. 278(34):31512-31520 (2003). Barbiero, L., et al., Exp. Neurol. 182(2):335-345 (2003). Shi, X.P., et al., J. Biol. Chem. 278(23):21286-21294 (2003). Kondoh, K., et al., Breast Cancer Res. Treat. 78(1):37-44 (2003).
Clonality	Polyclonal
Clone/Animal Names	RB2187
Gene ID	25825
Gene Name	BACE2
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	The anti-BACE2 Ctr Pab (Cat. #AP6121a) is used in Western blot to detect BACE2 in HL60 cell lysate.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Flow cytometric analysis of HL-60 cells using BACE2 Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 2	FC
Dilution image 2	1:10~50
Isotype	Rabbit Ig
Calculated MW	56180
Antigen Region	336-365
Antigen Source	HUMAN
Target/Specificity	This BACE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-365 amino acids from the Central region of human BACE2.
NCBI Accession	NP_036237.2; NP_620476.1; NP_620477.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 11/6/2025

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