LRP5 Antibody (C-term)

Synthetic Peptide

Low density lipoprotein (LDL) receptor-related protein (LRP), a member of the LDL receptor family, binds multiple classes of ligands and has been implicated in a broad range of normal and disease processes involving lipid metabolism, protease clearance, and cell migration. Structurally, members of the LDLR family share homology within their extracellular domains, which are highlighted by the presence of clusters of ligand-binding repeats. LRP is a large endocytic receptor that participates in several biological pathways and plays prominent roles in lipoprotein metabolism and in the catabolism of proteinases involved in coagulation and fibrinolysis. LRP also mediates the cellular entry of certain viruses and toxins and facilitates the activation of various lysosomal enzymes. All LRPs are expressed in the central nervous system and, for most receptors, animal models have shown that they are indispensable for successful neurodevelopment. The mechanisms by which they regulate the formation of the nervous system are varied and include the transduction of extracellular signals and the modulation of intracellular signal propagation, as well as cargo transport, the function most commonly attributed to this gene family.

Polyclonal

4041

Purified Rabbit Polyclonal Antibody (Pab)

LRP5 Antibody (C-term)(Cat. #AP6157a) is used in Western blot to detect recombinant human LRP5 (Lane 1) and mouse LRP5 (Lane 2) proteins in transfected 293 cell lysates. Data is kindly provided by Drs. V. Harris and S. Aaronson from the Mount Sinai School of Medicine (New York, NY).

1:1000

IHC-P

Q9UP66

179145

HUMAN

NP_002326.2