MAGEA1 Antibody (Center)

Synthetic Peptide

MAGEA1 is a member of the MAGEA gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 80% sequence identity between each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are expressed at a high level in a number of tumors of various histologic types, and are silent in normal tissues with the exception of testis and placenta. The MAGEA genes are clustered on chromosome Xq28. They may be implicated in some hereditary disorders, such as dyskeratosis congenita.

Polyclonal

4100

Purified Rabbit Polyclonal Antibody (Pab)

Western blot analysis of anti-MAGEA1 Antibody (Center) (RB02082) in Hela cell line lysates (35ug/lane). MAGEA1(arrow) was detected using the purified Pab.

1:1000

IHC-P

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with MAGEA1 Antibody (Center) (Cat.#AP6163a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

1:50~100

Rabbit Ig

143-173

This MAGEA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 143-173 amino acids from the Central region of human MAGEA1.