PARK8 (LRRK2) Antibody (L899)

Synthetic Peptide

Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson's disease identified to date. LRRK2, a genetic mutation, was recently found linked to about 5 percent of inherited cases of Parkinson's disease. By high-resolution recombination mapping and candidate gene sequencing in 46 families, 6 disease-segregating mutations (5 missense and 1 putative splice site mutation). It may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism. LRRK2 belongs to the ROCO protein family and includes a protein kinase domain of the MAPKKK class and several other major functional domains.

Polyclonal

120892

Purified Rabbit Polyclonal Antibody (Pab)

Western blot analysis of PARK8 (LRRK2) (arrow) using rabbit polyclonal PARK8 (LRRK2)Antibody (L899)(Cat# AP7099g). (A) 293 cell lysate (2 ug) transiently transfected with the PARK8 gene (Origene Technologies). (B) Mouse brain lysates (35ug/lane). PARK8 (arrow) was detected using the purified polyclonal antibody.

1:1000

WB

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

1:50~100

Rabbit Ig

931-962

This PARK8(LRRK2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 931-962 amino acids from human PARK8(LRRK2).