AKT1 Antibody (N-term)

Synthetic Peptide

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.

RB15679

AKT1

H

IF

Western blot analysis of AKT1 Antibody (N-term) (Cat. #AP7141h) in MCF-7 cell line lysates (35ug/lane). AKT1 (arrow) was detected using the purified Pab.

1:1000

FC

P47196; P31750; Q01314

Rabbit Ig

49-76

This AKT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-76 amino acids from the N-terminal region of human AKT1.